State of the body in disorders of diurnal physiological rhythms and long-term hypokinesia

In order to study the effects of hypokinesia and circadian rhythm restructuring on the morphological and functional status of the hypothalamo-hypophysic-adrenal system, young male Wistar rats were placed in small cages for varying periods. The animals were decapitated and preparations were made from sections of the brain and adrenals and numerous destructive changes were noted in the investigated regions of the brain, indicating that the condition of these areas is directly affected by disruption of established rhythms in physiological processes

Functional-morphological parallels of the hypothalamo-pituitary-adrenal system response reaction to long-term hypokinesia

The effect of 2 and 4 week hypokinesia regimens on the hypothalamo-pituitary-adrenal system (HPAS) was investigated in 110 inbred mice. Progressive exhaustion and pathological reorganization of the HPAS morphofunctional structures was revealed. On the basis of established facts of interlineary and interspecies differences in the HPAS response, it is suggested that the animal body response reaction to the long term effects of hypokinesia depends largely on its HPAS resistance and the values of this system's defensive adaptation potential

Wire GEM detector

A wire GEM (WGEM) detector with a gas gap between meshes was constructed. The detector provides the amplification 5x10E5 for the gas mixture of Ar +20% CO2 at atmospheric pressure. As compared with well-known GEM detectors produced by perforation the plastic plate metalized on both sides the WGEM does not suffer from breakdowns between its electrodes and the effect of accumulation of charges on holes walls is absent. As a result the WGEM has high reliability and stability.Comment: Presented at the RD51 Collaboration Meeting, CERN, November 2009, submitted to the Prib. Tech. Expe

RETGEM with polyvinylchloride (PVC) electrodes

This paper presents a new design of the RETGEM (Resistive Electrode Thick GEM) based on electrodes made of a polyvinylchloride material (PVC). Our device can operate with gains of 10E5 as a conventional TGEM at low counting rates and as RPC in the case of high counting rates without of the transit to the violent sparks. The distinct feature of present RETGEM is the absent of the metal coating and lithographic technology for manufacturing of the protective dielectric rms. The electrodes from PVC permit to do the holes by a simple drilling machine. Detectors on a RETGEM basis could be useful in many fields of an application requiring a more cheap manufacturing and safe operation, for example, in a large neutrino experiments, in TPC, RICH systems.Comment: Presented at the RD51 Collaboration Meeting, CERN, November 200

Spatially resolved microwave pulsations of a flare loop

A microwave burst with quasi-periodic pulsations was studied with high spatial resolution using observations with the Nobeyama Radioheliograph (NoRH). We found that the time profiles of the microwave emission at 17 and 34 GHz exhibit quasi-periodic (with two well defined periods P 1 = 14–17 s and P 2 = 8–11 s) variations of the intensity at different parts of an observed flaring loop. Detailed Fourier analysis shows the P 1 spectral component to be dominant at the top, while the P 2 one near the feet of the loop. The 14–17 s pulsations are synchronous at the top and in both legs of the loop. The 8–11 s pulsations at the legs are well correlated with each other but the correlation is not so obvious with the pulsations at the loop top. For this P 2 spectral component, a definite phase shift, P 2 /4 ≈ 2.2 s, between pulsations in the northern leg and loop top parts of the loop have been found. The length of the flaring loop is estimated as L = 25 Mm (≈34 ) and its average width at half intensity at 34 GHz as about 6 Mm (≈8 ). Microwave diagnostics shows the loop to be filled with a dense plasma with the number density n 0 ≈ 10 11 cm −3, penetrated by the magnetic field changing from B 0 ≈ 100 G near the loop top up to B 0 ≈ 200 G near the north footpoint. A comparative analysis of different MHD modes of the loop demonstrates the possibility of the simultaneous existence of two modes of oscillations in the loop: the global sausage mode, with the period P 1 = 14–17 s and the nodes at the footpoints, and a higher harmonics mode (possibly with the radial wave number l > 1), with P 2 = 8–11 s

MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix

Aim. CO326 is a chicken nuclear scaffold/matrix attachment region (MAR) associated with the nuclear matrix in several types of chicken cells. It contains a binding site for a sequence-specific DNA-binding protein, F326. We have studied its interaction with the nuclear matrix. Methods. We have used an in vitro MAR assay with isolated matrices from chicken HD3 cells. Results. We have found that an oligonucleotide binding site for the F326 inhibits binding of the CO326 to the nuclear matrix. At the same time, the binding of heterologous MARs is enhanced. Conclusions. Taken together, these data suggest that there exist several classes of MARs and MAR-binding domains and that the MAR-binding proteins may be clustered in the nuclear matrix

The upstream area of the chicken α-globin gene domain is transcribed in both directions in the same cells

AbstractIt was demonstrated previously that in erythroid chicken cells an extended upstream area of the α-globin gene domain is transcribed in both directions as a part of ggPRX gene and a part of a full domain transcript of the α-globin gene domain. Here, we show that both DNA chains of the above-mentioned region are transcribed in the same cells and that the corresponding transcripts coexist in nuclei. The data obtained suggest that cells possess a molecular mechanism which in some cases prevents the formation of dsRNA and subsequent destruction of both transcripts in spite of the presence of complementary RNA chains in the cell nucleus

Selandian-Thanetian larger foraminifera from the lower Jafnayn Formation in the Sayq area (eastern Oman Mountains)

The larger foraminifera of the lower part of the Jafnayn Formation outcropping in the Wadi Sayq, in the Paleocene series of the eastern Oman Mountains, have been studied and described in detail. The analysis have allowed us to develop a detailed systematic description of each taxa, constraining their biostratigraphic distribution and defining the associated foraminifera assemblages. The taxonomic study has permitted us to identify each morphotype precisely and describe three new taxa, namely, Ercumentina sayqensis n. gen. n. sp. Lacazinella rogeri n. sp. and Globoreticulinidae new family. The first assemblage is characterized by the presence of Coskinon sp., Dictyoconus cf. turriculus Hottinger and Drobne, Anatoliella ozalpiensis Sirel, Ercumentina sayqensis n. gen. n. sp. Serra-Kiel and Vicedo , Lacazinella rogeri n. sp. Serra-Kiel and Vicedo, Mandanella cf. flabelliformis Rahaghi, Azzarolina daviesi (Henson), Lockhartia retiata Sander, Dictyokathina simplex Smout and Miscellanites globularis (Rahaghi). The second assemblage is constituted by the forms Pseudofallotella persica (Hottinger and Drobne), Dictyoconus cf. turriculus Hottinger and Drobne, Lacazinella rogeri n. sp. Serra-Kiel and Vicedo, Azzarolina daviesi (Henson), Keramosphera? cf. iranica Rahaghi, Lockhartia haimei (Davies), Lockhartia retiata Sander, Sakesaria trichilata Sander, Kathina delseota Smout, Elazigina harabekayisensis Sirel, Daviesina khatiyahi Smout, and Miscellanea juliettae Leppig. The first assemblage can be considered to belong to the Shallow Bentic Zone SBZ2 (early Selandian age), and the second assemblage to the SBZ3 (late Selandian-early Thanetian age).This paper shows, for the first time in the Middle East area, a correlation between the Selandian larger foraminifera and planktonic foraminifera biozones